Biological Importance and Statistical Significance

Statistical significance in biological sequence analysis

One of the major goals of computational sequence analysis is to find sequence similarities, which could serve as evidence of structural and functional conservation, as well as of evolutionary relations among the sequences. Since the degree of similarity is usually assessed by the sequence alignment score, it is necessary to know if a score is high enough to indicate a biologically interesting a...

Statistical Significance in Biological Sequence Comparison1

The statistical significance of biological data.

The pathological and clinical (may I even say surgical ?) approach has thus furnished us with a working hypothesis on which the function of the thymus gland may eventually be elucidated. There are still many difficulties in the way of a final solution, and progress is likely to be slow. It may be thought safer to return for the present to Galen's belief that the thymus is just a cushion to prot...

Economic Importance and Statistical Significance : Guidelines for Communicating

A critical objective for many empirical studies is a thorough evaluation of both substantive importance and statistical significance. Feminist economists have critiqued neoclassical economics studies for an excessive focus on statistical machinery at the expense of substantive issues. Drawing from the ongoing debate about the rhetoric of economic inquiry and significance tests, this paper exami...

Significance and Biological Importance of Pyrimidine in the Microbial World

Microbes are unique creatures that adapt to varying lifestyles and environment resistance in extreme or adverse conditions. The genetic architecture of microbe may bear a significant signature not only in the sequences position, but also in the lifestyle to which it is adapted. It becomes a challenge for the society to find new chemical entities which can treat microbial infections. The present...